https://ogma.newcastle.edu.au/vital/access/ /manager/Index ${session.getAttribute("locale")} 5 Airway mucins promote immunopathology in virus-exacerbated chronic obstructive pulmonary disease https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:45554 Muc5ac-deficient (Muc5ac–/–) mice had attenuated RV-induced (RV-induced) airway inflammation, and exogenous MUC5AC glycoprotein administration augmented inflammatory responses and increased the release of extracellular adenosine triphosphate (ATP) in mice and human airway epithelial cell cultures. Hydrolysis of ATP suppressed MUC5AC augmentation of RV-induced inflammation in mice. Therapeutic suppression of mucin production using an EGFR antagonist ameliorated immunopathology in a mouse COPD exacerbation model. The coordinated virus induction of MUC5AC and MUC5B expression suggests that non-Th2 mechanisms trigger mucin hypersecretion during exacerbations. Our data identified a proinflammatory role for MUC5AC during viral infection and suggest that MUC5AC inhibition may ameliorate COPD exacerbations.]]> Tue 01 Nov 2022 11:18:46 AEDT ]]> ITGB4 deficiency induces mucus hypersecretion by upregulating MUC5AC in RSV-infected airway epithelial cells https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:45382 Thu 27 Oct 2022 16:12:30 AEDT ]]> Blocking notch3 signaling abolishes MUC5AC production in airway epithelial cells from individuals with asthma https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:46730 Thu 01 Dec 2022 10:28:14 AEDT ]]> The genetic architecture of pneumonia susceptibility implicates mucin biology and a relationship with psychiatric illness https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:51343 Fri 01 Sep 2023 13:34:03 AEST ]]>